cGMP  

Catalog Number: 26001-1 

Description: Anti-cGMP Mouse Monoclonal Antibody

Background: cGMP is a ubiquitous second  messenger mediating cellular responses to various 

 exogenous and endogenous signaling molecules.  cGMP regulates physiological processes by  

activating protein kinases, gating specific ion  channels, and modulating cellular cyclic nucleotide

concentrations through phosphodiesterases. The  conversion of GTP to cGMP is catalyzed by 

guanylyl cyclases (GCs). There are two types of  GCs in mammals: the soluble and the  membrane-bound

 GCs. The soluble GCs are  generally activated when nitric 

oxide binds to the attached prosthetic heme group. Seven  membrane-bound GCs (also named 

transmembrane  or particulated GCs) have been identified in the  human genome. GC-A and 

GC-B are natriuretic  peptide receptors. GC-C can be activated by  bacterial heat-stable enterotoxins,

 guanylin and  uroguanylin. The activity of transmembrane GCs  can also be 

modulated by other receptor signals  through intracellular signaling pathways.  

Immunogen: cGMP 

Tested applications: ELISA, WB, IHC  

Recommended dilutions: ELISA 1:1000-1:5000,  WB 1:1000-1:2000,  

Host: mouse  Clonality: Monoclonal  

Isotype: IgG  

Purity: Purified from ascites  

Format: Liquid  

Storage buffer:  

   Preservative: no 

   Constituents: PBS (without Mg2+ and Ca2+), pH 7.4

Storage Conditions: Store at -20°C. Avoid freeze /  thaw cycles

Sensitivity