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| 价格 | 询价 |
| 品牌 | Bioyears  |
| 产地 | 中国 |
| 货号 | BYX-P-009 |
| CAS号 | N |
| 分子式 | C₇₉H₁₃₁N₃₁O₂₄S₄ |
| 分子量 | 2027.34 |
| 技术资料 | 查看技术资料 |
| 生物活性 | Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1]. |
|---|---|
| IC50 & Target | K+ channel[1] |
| 体外研究 (In Vitro) | Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1[1]. Cell Line:HSC-T6 cellsConcentration:0.5 µg/mL, 1 µg/mL and 2 µg/mLIncubation Time:24 hoursResult:Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1. |
| 体内研究 (In Vivo) | Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice[1]. Animal Model:8-week-old C57BL/6 male mice (20-25 g) with DDC feeding[1]Dosage:0.1 mg/kgAdministration:Intraperitoneal injection; twice a week; for 4 weeksResult:Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice. |
| 分子量 | 2027.34 |
| Formula | C₇₉H₁₃₁N₃₁O₂₄S₄ |
| CAS 号 | 24345-16-2 |
| Sequence | Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15) |
| Sequence Shortening | CNCKAPETALCARRCQQH-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15) |
| 中文名称 | 蜂毒明肽 |
| 运输条件 | Room temperature in continental CN; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
电话： 027-87561633
邮箱： Bioyears@126.com
电话： 027-87561633
邮箱： Bioyears@126.com
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