Anti Gαi Rabbit Polyclonal Antibody

价格	2600.00
品牌	Bioyears
产地	美国
货号	21006
免疫原	Rabbit
规格	100μl
技术资料	查看技术资料

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概述

Gαi [21006]
[100 µL]

Catalog Number: 21006

Gene Symbol: Gα_i

Description: Anti Gα_i Rabbit Polyclonal Antibody

Background: Heterotrimeric G proteins are critical cellular signal transducers. Gα_i represents one sub-family of G proteins that could mediate the inhibition of adenylyl cyclases. Other biochemical and physiological functions of Gα_i proteins are being explored.

Immunogen: Recombinant full length protein of Gα_i1

Applications: ELISA, WB, IHC

Recommended Dilutions: ELISA 1:100-1:5000, WB 1:100-1:2000

Concentration: 1 mg/ml

Host: Rabbit

Format: Liquid

Clonality: Polyclonal

Isotype:

Purity: Purified from serum

Storage buffer:

Preservative: no

Constituents: PBS (without Mg ²⁺and Ca ²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: Gα_i antibody recognizes Gα_i1, Gα_i2, and Gα_i3 of vertebrates

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Western blot:

Western blot analysis of Gi proteins. Gα_i1 plasmid DNA was transiently transfected into HEK-293 cells. Whole-cell lysate was used for western blot with the polyclonal anti Gα_i antibody (cat # 21006).

Publications:

1. Identification of novel signalling roles and targets for Galpha and Gbetagamma downstream of the insulin-like growth factor 1 receptor in vascular smooth muscle cells
Biochem J. 2013 Feb 15;450(1):209-19

2. CRH activation of different signaling pathways results in differential calcium signaling in human pregnant myometrium before and during labor
J Clin Endocrinol Metab. 2012 Oct;97(10):E1851-61

3. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma
Cancer Res. 2012 Jan 1;72(1):122-32

4. Regulation of estradiol and progesterone production by CRH-R1 and -R2 is through divergent signaling pathways in cultured human placental trophoblasts
Endocrinology. 2012 Oct;153(10):4918-28

5. WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins
Cell Signal. 2011 Mar;23(3):550-4

6. Heterotrimeric Galpha(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
Biochim Biophys Acta. 2011 Mar;1813(3):466-72

7. Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I
Steroids Volume 77, Issue 5,

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