武汉天德生物科技有限公司欢迎您！
366577646@qq.com
366577646@qq.com
| 027-87561633
027-87561633366577646@qq.com
| 价格 | 2600.00 |
| 品牌 | Bioyears  |
| 产地 | 美国 |
| 货号 | 21005 |
| 免疫原 | Rabbit |
| 规格 | 100μl |
| 技术资料 | 查看技术资料 |
Gα13 [21005]
[100 µL]
| Catalog Number: 21005 |
| Gene Symbol: Ga13 |
| Description: Anti Gα13 Rabbit Polyclonal Antibody |
| Background: Heterotrimeric G proteins are essential cellular signal transducers. Gα13 is one of the G proteins that could mediate cell migration and angiogenesis. Other biochemical and physiological functions of Gα13 are being explored. |
| Immunogen: Recombinant full length Gα13 protein |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA 1:100-1:5000 WB 1:100-1:2000 IHC 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host: Rabbit |
| Format: Liquid |
| Clonality: Polyclonal |
| Isotype: |
| Purity: Purified from serum |
| Storage buffer: |
| Preservative: no |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Gα13 polyclonal antibody recognizes Gα13 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles |
| Western blot: |
 | Western blot analysis of Gα13 proteins. MEF whole-cell lysates were used for western blot with anti Gα13polyclonal antibody (Cat. # 21005). |
| Immunofluorescence: |
| Immunofluorescence of mouse embryonic fibroblast (MEF) cells. Wild-type MEF cells (top panel) and Gα13 double knock-out cells (Gα13 -/-, bottom panel) were fixed and stained with anti-Gα13 polyclonal antibody (Cat. # 21005). Arrows indicate the dorsal ruffle strcture of one cell. |
| Publications: |
| 1. Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization J Biol Chem. 2011 Sep 2;286(35):31055-61 |
| 2. Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Galpha and beta-arrestin-2 Br J Pharmacol. 2011 Feb;162(3):733-48 |
| 3. Gα12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation Carcinogenesis (2010) |
| 4. Suppression of tumor angiogenesis by Galpha(13) haploinsufficiency J Biol Chem. 2009 Oct 2;284(40):27409-15 |
电话： 027-87561633
邮箱： Bioyears@126.com
电话： 027-87561633
邮箱： Bioyears@126.com
地址： 武汉市东湖开发区关东科技工业园3#产业区3-3栋15号
