Gene Symbol: Beta-catenin, CTNNB, Catenin beta-1

Description: Anti-CTNNB1 (S33F) Mouse Monoclonal Antibody

Background: CTNNB1 protein is a dual function protein. It is a subunit of a complex of proteins that from adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells. CTNNB1 protein also pulls double duty as an intracellular signal transducer in the Wnt signaling pathway. Mutant CTNNB1 (ß-catenin) has been implicated in the pathogenesis of several cancers including melanoma, colorectal cancer, hepatocelluar carcinoma, and ovarian cancerMutations of CTNNB1 have been implicated in the pathogenesis of several cancersis part of a complex of proteins that form adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells is part of a complex of proteins that form adherens junctions, which are important for the establishment and maintenance of epithelial cell layers by regulating cell growth and adhesion between adjacent cells

Immunogen: A synthetic peptide from the internal region of CTNNB1 which includes the mutation of S33F, human origin

Recommended Dilutions:

ELISA:  1:1000-1:5000

WB:     1:500-1:1000

IHC:     1:50-1:100